Table 3.

Nerve density and number changes via IVCM measurements.

	Normal	Pre-treatment NK	Post-treatment NK	p value
Total nerve density in mm/mm2	22.7 ± 4.0; 22.3 (14.9–29.0)	4.6 ± 6.1; 2.3 (0.0–21.1)	6.4 ± 5.8; 5.3 (0.0–19.4)	°p < 0.0001 •p < 0.0001 ×p = 0.0083
Main nerve density in mm/mm2	10.1 ± 2.2; 10.1 (3.2–15.4)	2.6 ± 3.2; 1.7 (0.0–13.0)	3.7 ± 3.3; 3.5 (0.0–13.2)	°p < 0.0001 •p < 0.0001 ×p = 0.0059
Branch nerve density in mm/mm2	12.5 ± 3.2; 12.1 (6.2–18.4)	2.1 ± 3.3; 0.5 (0.0–10.2)	2.7 ± 2.8; 2.0 (0.0–10.4)	°p < 0.0001 •p < 0.0001 ×p = 0.0251
Total nerve number in n/mm2	155.6 ± 44.4; 157.5 (51.9–225.0)	21.9 ± 28.8; 10.6 (0.0–90.6)	29.4 ± 28.8; 20.6 (0.0–105.0)	°p < 0.0001 •p < 0.0001 ×p = 0.0118
Main nerve number in n/mm2	35.0 ± 46.3; 25.0 (16.9–37.5)	7.5 ± 8.1; 6.3 (0.0–33.1)	10.0 ± 8.8; 8.1 (0.0–38.8)	°p < 0.001 •p < 0.001 ×p = 0.0162
Branch nerve number in n/mm2	130.6 ± 42.5; 131.3 (31.3–195.6)	14.4 ± 22.5; 4.4 (0.0–64.4)	19.4 ± 21.3; 13.8 (0.0–82.5)	°p < 0.0001 •p < 0.0001 ×p = 0.0256

Results are presented as mean ± SD; median (range). Presented p values compare ^•control vs pre-treatment NK, ^°control vs post-treatment, ^×pre-treatment vs post-treatment.