Table 5.
Summary of clinical findings pre- and post-rhNGF treatment.
| Test | Pre-treatment | Post-treatment | p value |
|---|---|---|---|
| Corneal sensation (Cochet-Bonnet esthesiometry) | 2.3 ± 1.1; 2.5 (0.5–4) |
4.1 ± 1.4; 4.5 (0.5–6) |
0.001 |
| Corneal fluorescein staining (Oxford scale) | 3.1 ± 1.4; 3.0 (0.0–5.0) |
1.9 ± 1.3; 2.0 (0.0–5.0) |
0.001 |
| Tear break-up time (TBUT, seconds) | 5.2 ± 2.4; 5.0 (2.0–10.0) |
6.1 ± 4.1; 6.0 (0.0–18.0) |
0.490 |
| Intraocular pressure (IOP, mmHg) | 16.1 ± 4.4; 16.0 (8.0–27.0) |
15.8 ± 4.5; 15.0 (9.0–27.0) |
0.680 |
| Schirmer’s test with anesthesia (mm) | 8.58 ± 6.0; 8.0 (1.0–16.0) |
7.25 ± 6.6; 4.0 (1.0–16.0) |
0.058 |
| Best corrected visual acuity (logMAR) | 0.4 ± 0.4; 0.4 (0–1.6) |
0.3 ± 0.4; 0.1 (−0.1–1.6) |
0.007 |
Results are presented as mean ± SD; median (range).
Bold values indicate significant p values.