Table 7.
Pharmacokinetic parameters of 8 mg MBO and 20 mg PZQ after oral administration to cats (n = 6).
| Parameters | MBO | PZQ | C-4-OH-PZQ | T-4-OH-PZQ |
|---|---|---|---|---|
| t1/2 (h) | 49.91 ± 22.71 | 2.71 ± 0.80 | 3.19 ± 0.73 | 4.72 ± 2.67 |
| Tmax (h) | 4.33 ± 1.37 | 3.67 ± 1.86 | 4.00 ± 1.67 | 3.83 ± 1.83 |
| Cmax (ng/mL) | 251.36 ± 59.27 | 637.54 ± 351.34 | 262.69 ± 36.19 | 117.48 ± 36.69 |
| AUC0-t (ng·h/mL) | 4820.76 ± 2054.46 | 3593.22 ± 2079.93 | 1521.50 ± 156.60 | 664.87 ± 183.26 |
| AUC0-∞ (ng·h/mL) | 5267.86 ± 2199.14 | 3701.29 ± 2080.69 | 1616.80 ± 190.09 | 768.83 ± 214.41 |
| Vz/F (L/kg) | 33.97 ± 10.81 | 8.20 ± 5.50 | 17.64 ± 4.03 | 51.95 ± 14.72 |
| CL/F (L/h/kg) | 0.54 ± 0.25 | 2.08 ± 1.03 | 3.89 ± 0.72 | 8.55 ± 2.08 |