Table 4.

Univariate and Multivariate Analyses of Prognostic Factors Affecting OS

Variable	Univariate Cox Analysis			Multivariate Cox Analysis
	HR	95% CI	P-value	HR	95% CI	P-value
Sex (male vs female)	2.528	0.589–10.854	0.196
Age(<55 vs ≥55)	0.875	0.441–1.736	0.703
ECOG PS (0 vs.1/2)	2.331	0.107–4.907	0.720
Extrahepatic metastasis (yes vs no)	0.705	0.305–1.631	0.364
BED (<50Gy vs ≥50Gy)	0.792	0.399–1.567	0.502
GTV (<544mL vs ≥544mL)	1.370	0.678–2.768	0.358
Child-Pugh (Grade A vs Grade B)	0.736	0.322–1.686	0.430
AFP (<400ng/mL vs ≥400ng/mL)	1.104	0.557–2.189	0.776
*AFP dropped to normal (yes vs no)	0.141	0.068–0.295	0.0009	0.145	0.032–0.648	0.011
#AFP reduced by half (yes vs no)	2.468	1.201–5.071	0.011	0.629	0.303–1.303	0.212
Previously treated with TACE (yes vs no)	0.888	0.448–1.762	0.731

Notes: *AFP dropped to normal 3 months after radiotherapy. #AFP reduced by half 1 month after radiotherapy. Statistically significant data has been highlighted in red according to multivariate cox analysis.

Abbreviations: ECOG PS, Eastern Cooperative Oncology Group Performance Status; BED, Equivalent Biological Dose; GTV, Gross Tumor Volume; AFP, a-fetoprotein; TACE, Transcatheter arterial chemoembolization/.