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. 2023 Oct 27;15(10):1127–1139. doi: 10.4254/wjh.v15.i10.1127

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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Selection of patient cohorts. ¹In total, 135 patients had only one outpatient alterations in plasma protein metabolism (APPM) diagnosis and therefore did not meet these criteria; ²In total, 42 patients with fibrosis in the APPM cohort progressed to cirrhosis during follow-up; and ³In total, 280 patients with fibrosis in the control cohort progressed to cirrhosis during follow-up. ICD-10-GM: German Modification of the International Classification of Diseases-10^th Revision.