Table 3.

Procedures indicating disease progression stratified by fibrosis or cirrhosis

Parameter	Patients with fibrosis				Patients with cirrhosis
	Liver resection		Liver transplantation		Liver resection		Liver transplantation
	Patients with APPM, n = 96	Patients without APPM, n = 1445	Patients with APPM, n = 96	Patients without APPM, n = 1445	Patients with APPM, n = 2626	Patients without APPM, n = 25134	Patients with APPM, n = 2626	Patients without APPM, n = 25134
Patients with event during follow-up	15 (15.6)	93 (6.4)	6 (6.3)	3 (0.2)	87 (3.3)	488 (1.9)	78 (3.0)	31 (0.1)
Patients included in the KM analysis1	85 (88.5)	1373 (95.0)	94 (97.9)	1442 (99.8)	2606 (99.2)	24849 (98.9)	2621 (99.8)	25034 (99.6)
Median follow-up in patients without an event, yr (IQR)2	2.3 (0.7-5.0)	3.0 (1.2-5.2)	2.3 (0.7-4.7)	2.8 (1.2-5.1)	1.5 (0.4-3.7)	1.9 (0.5-4.4)	1.5 (0.4-3.7)	1.9 (0.5-4.4)
Failure rate
After 1 yr	3 (4.2)	15 (1.2)	1 (1.2)	1 (0.1)	40 (2.0)	198 (1.0)	26 (1.4)	8 (< 0.1)
After 3 yr	3 (4.2)	18 (1.5)	3 (4.8)	1 (0.1)	56 (3.4)	258 (1.5)	53 (3.6)	23 (0.2)
After 5 yr	3 (4.2)	20 (1.9)	4 (7.3)	1 (0.1)	64 (4.7)	289 (1.9)	66 (5.6)	25 (0.2)
P value (log-rank test)	0.025		< 0.001		< 0.001		< 0.001

Data are n (%) unless otherwise indicated.

¹Patients with the event on the index date were excluded from the Kaplan-Meier (KM) analysis. As there were no patients with liver incision in the alterations in plasma protein metabolism cohort, and only one patient in the control cohort, this outcome is not reported.

²There were no patients with fibrosis who had an infection/inflammatory reaction due to prothesis/implant/graft. For one patient in the control cohort, the index date and end date were the same; this patient was automatically excluded from the KM analysis. Median follow-up in patients without the event was estimated via the reverse KM method.

IQR: Interquartile range; APPM: Alterations in plasma protein metabolism.