Fig. 37. DNA nanotags. (A) Schematic of DNA nanotags and their formation based on intercalation of YOYO-1 dye into dsDNA assemblies. (B) Fluorescent DNA nanotags: linear (1-D), 3-way junction (2-D), and tetrahedron (3-D) Scale bar = 8.5 nm. (C) Fluorescence intensity of YOYO-1 as a function of the nanotag shape and the dye/bp ratio. (D) Photostability of the DNA nanotags. Interesting to note that not only is the tetrahedron structure more stable against enzyme and medium degradation but the YOYO-1 is also more photostable in the tetrahedron. Reproduced with permission from ref. 357 Copyright 2009 American Chemical Society.
