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. Author manuscript; available in PMC: 2023 Nov 13.
Published in final edited form as: Vaccine. 2022 Jun 3;40(31):4121–4127. doi: 10.1016/j.vaccine.2022.05.077

Table 3.

Population RSV hospitalization burden estimates based on total acute respiratory infection (ARI) hospitalizations and ARI-related* hospitalizations.

Time period or group Total ARI hospitalizations
ARI-related hospitalizations
Calculated RSV cases in county hospitals** (a) RSV cases per 100,000 population (a/n)*100,000 Calculated RSV cases in county hospitals** (b) RSV cases per 100,000 population (b/n)*100,000
Burden of RSV for Allegheny County adult population (≥18 years)
(a) Total adults, n = 984,996 (b) Total adults, n = 984,996
9/2015–8/2016 2321.6 236 - 1456.5 148 -
Fall 2015 43.2 4 - 27.0 3 -
Winter 2015 1019.2 103 - 618.3 63 -
Spring 2016 652.4 66 - 391.6 40 -
Summer 2016 57.8 6 - 39.3 4 -
9/2016–8/2017 3758.5 382 - 2364.2 240 -
Fall 2016 296.2 30 - 190.6 19 -
Winter 2016 1427.5 145 - 812.6 83 -
Spring 2017 906.6 92 - 571.9 58 -
Summer 2017 0.0 0 - 0.0 0 -
9/2017–8/2018 3465.0 352 - 2231.8 227 -
Fall 2017 247.3 25 - 163.9 17 -
Winter 2017 1223.2 124 - 705.8 72 -
Spring 2018 1003.0 102 - 643.3 65 -
Summer 2018 173.5 18 - 122.4 12 -
3-year average 3181.7 323 - 2017.5 205 -
Burden of RSV for Allegheny County immunocompetent adult population (≥18 years)
(a) Total adults n = 984,996 Immunocompetent adults n = 955,447 (b) Total adults n = 984,996 Immunocompetent adults n = 955,447
9/2015–8/2016 1923.9 195 201 1215.3 123 127
9/2016–8/2017 3298.4 335 345 2086.0 212 218
9/2017–8/2018 3054.6 310 320 1976.3 201 207
3-year average 2759.0 280 289 1759.2 179 184
Burden of RSV for Allegheny County non-pregnant adult population (≥18 years)
(a) Total adults n = 984,996 Non-pregnant adults n = 971,822 (b) Total adults n = 984,996 Non-pregnant adults n = 971,822
9/2015–8/2016 2285.9 232 235 1419.1 144 146
9/2016–8/2017 3664.6 372 377 2284.0 232 235
9/2017–8/2018 3393.5 345 349 2163.9 220 223
3-year average 3114.6 316 320 1955.7 199 201
Burden of RSV for Allegheny County adult population (18–64 years)
(a) Total adults n = 984,996 Adults 18–64 years n = 753,948 (b) Total adults n = 984,996 Adults 18–64 years n = 753,948
9/2015–8/2016 587.7 60 78 381.4 39 51
9/2016–8/2017 1176.7 119 156 767.9 78 102
9/2017–8/2018 903.5 92 120 603.7 61 80
3-year average 889.3 90 118 584.4 59 78
Burden of RSV for Allegheny County adult population (≥65 years)
(a) Total adults n = 984,996 Adults ≥ 65 years n = 231,049 (b) Total adults n = 984,996 Adults ≥ 65 years n = 231,049
9/2015–8/2016 1619.2 164 701 993.4 101 430
9/2016–8/2017 2485.6 252 1076 1526.8 155 661
9/2017–8/2018 2403.8 244 1040 1513.0 154 655
3-year average 2169.5 220 939 1344.4 136 582
Burden of RSV for Allegheny County immunosuppressed population (≥18 years)
(a) Total adults n = 984,996 Immunosuppressed adults n = 29,550 (b) Total adults n = 984,996 Immunosuppressed adults n = 29,550
9/2015–8/2016 380.7 39 1288 228.7 23 774
9/2016–8/2017 461.7 47 1562 279.3 28 945
9/2017–8/2018 411.4 42 1392 256.1 26 867
3-year average 417.9 42 1414 254.70 26 862
Burden of RSV for Allegheny County pregnant population (20–44 years)
(a) Total adults n = 984,996 Pregnant women n = 13,174 (b) Total adults n = 984,996 Pregnant women n = 13,174
9/2015–8/2016 0.0 0 0 0.0 0 0
9/2016–8/2017 106.5 11 808 96.4 10 732
9/2017–8/2018 56.8 6 431 51.6 5 392
3-year average 81.7 8 620 74.0 8 562
*

ARI-related hospitalization = those hospitalized with a high-risk condition exacerbated by an ARI.

**

See Appendix 2 for equations 15

See Appendix 2 for equations 6 & 7

Includes solid organ transplants, n estimated at 3% of the adult population.