Figure 7.

Potential downstream targets of Ca²⁺/calmodulin-dependent protein kinase II (CaMKII) underlying long-term potentiation (LTP). 1) CaMKII modifies α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR)-transmembrane AMPAR-regulatory protein (TARP) complex (Receptor). 2) CaMKII modifies the postsynaptic density (PSD). 3) CaMKII modifies the exocytosis of AMPAR/TARP (Vesicle). Only 6 of the 12 subunits are shown for CaMKII. This diagram is not meant to reflect the nanodomain distribution of receptors within the PSD.