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. 2023 Jul 17;55(10):452–467. doi: 10.1152/physiolgenomics.00019.2023

Figure 6.

Figure 6.

Expression of the glucocorticoid receptor and genes associated with corticosteroid processing between study 1 (S1) and study 2 (S2) in wild-type (WT) and Krtcap3 knockout (KO) rats. We measured expression of nuclear receptor subfamily 3 group C member 1 (Nr3c1), 11β-hydroxysteroid dehydrogenase isoform 1 (Hsd11β1), and 11β-hydroxysteroid dehydrogenase isoform 2 (Hsd11β2) in liver and retroperitoneal fat (RetroFat) tissue of rats from both studies. A: in the liver, study 1 WT (black) and KO (gray) rats had significantly higher expression of NR3C1 compared to study 2 rats, with no differences by genotype. B and C: similarly, study 1 rats of both genotypes had higher expression of Hsd11β1 (B) and Hsd11β2 (C) when compared to study 2 rats. D: in the RetroFat, study 1 WT and KO rats had slightly higher Nr3c1 when compared to study 2 rats. E and F: there were no differences in Hsd11β1 expression between the 2 studies (E), but study 2 rats had significantly higher Hsd11β2 compared to study 1 rats (F). HFD, high-fat diet. #P < 0.1, ***P < 0.001, ****P < 0.0001, main effect of study.