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Multivariate Analyses of Apixaban Concentration Data for 5 mg Twice Daily Per Label
| Peak Concentration |
Trough Concentration |
|||||
|---|---|---|---|---|---|---|
| Estimate (ng/mL) | (95% CI) | R2 | Estimate (ng/mL) | (95% CI) | R2 | |
| Female vs male | 65.9 | (31.5–100.2) | 0.34 | 25.9 | (0.2–51.5) | 0.17 |
| 1 Additional daily medication | 11.0 | (4.4–17.6) | 6.4 | (1.5–11.3) | ||
| Per 10 mL/min decrease creatinine clearance | 13.8 | (5.0–22.7) | 7.0 | (0.2–13.8) | ||
