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. 2023 Oct 27;9(11):e21237. doi: 10.1016/j.heliyon.2023.e21237

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© 2023 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Fig. 7 — Histomicrograph of PCOS rat's ovary showing exogenous melatonin effect. (a) Control (CON) group exhibiting normal architecture. (b) Letrozole (LET) treatment caused the formation of cystic follicles, and decreased the number of different categories of follicles. Thickness and diameter of theca layer in the PCOS group increased significantly, while as diameter and thickness of granulose cells decreased significantly compared to the control group of rats. (c) Melatonin (MEL) administration maintained the normal ovarian structure. (d) Letrozole (LET) + Melatonin (MEL) administration restored the various parameters of folliculogenesis towards normal. CF: Cystic follicle, NF: normal follicle, CL: corpus luteum.