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. 2023 Nov 13;30(11):1806–1815. doi: 10.1038/s41594-023-01136-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 8 — a. COSMIC database analysis. AIFM2 somatic mutations (heterozygous) are found in cancer patients. Mutations can affect the enzymatic activity of FSP1, such as the proton transfer function (E160, K355), NADH binding (G244), and FAD binding (D285), and may affect the efficacy of FSP1 inhibitors (T327). b. DepMap database analysis. The S6 mutation likely affects FSP1 enzymatic activity via altered myristoylation (consensus motif: MGxxxS). c. Representative sequence data for genomic DNA of AIFM2 1 surrounding G337G/D extracted from SKOV3.