TABLE 3.
Metabolism-focused gene set enrichment analysis of M1 and M2 subtypes.
| Enriched metabolic pathways | Normalized enrichment score (NES) | Nominal p-value | FDR (q-value) |
|---|---|---|---|
| Glucagon signaling in metabolic regulation* | 2.08 | 0.000 | 0.002 |
| Glycogen metabolism* | 1.79 | 0.006 | 0.094 |
| Regulation of insulin secretion* | 1.55 | 0.039 | 0.251 |
| Metabolism of water-soluble vitamins and cofactors | 1.57 | 0.017 | 0.267 |
| Sphingolipid | 1.59 | 0.026 | 0.321 |
| Phase II conjugation of compounds | 1.50 | 0.031 | 0.292 |
| Triglyceride metabolism | 1.46 | 0.045 | 0.312 |
* = Significant based on both nominal p-value (≤0.05) and FDR (≤0.25).