Table 3. Incidence of ADEs associated with remdesivir in a population with renal impairment compared with matched controls.
| Type of ADEs | Total patients | No. of patients with ADEs | No. of patients with severe ADEs | ||||
|---|---|---|---|---|---|---|---|
| eGFR ≥ 30 mL/min (n = 500) | eGFR < 30 mL/min (n = 125) | P value | eGFR ≥ 30 mL/min (n = 500) | eGFR < 30 mL/min (n = 125) | P value | ||
| Any ADEs | 625 | 359 (71.8) | 100 (80.0) | 0.063 | 80 (16.0) | 51 (40.8) | < 0.001 |
| Hepatic injury | 596 | 212 (44.5) | 59 (49.2) | 0.363 | 16 (3.4) | 10 (8.3) | 0.017 |
| Renal injury | 583 | 47 (9.8) | 22 (21.0) | 0.001 | 10 (2.1) | 7 (6.7) | 0.020 |
| Hyponatremia | 597 | 87 (18.4) | 41 (33.1) | < 0.001 | 7 (1.5) | 7 (5.7) | 0.013 |
| Hypernatremia | 597 | 41 (8.7) | 14 (11.3) | 0.369 | 10 (2.1) | 3 (2.4) | 0.739 |
| Hypokalemia | 597 | 83 (17.6) | 29 (23.4) | 0.138 | 22 (4.7) | 11 (8.9) | 0.067 |
| Hyperkalemia | 597 | 30 (6.3) | 27 (21.8) | < 0.001 | 14 (3.0) | 13 (10.5) | < 0.001 |
| Hypocalcemia | 489 | 54 (14.3) | 22 (20.0) | 0.143 | 2 (0.5) | 2 (1.8) | 0.220 |
| Hypercalcemia | 489 | 4 (1.1) | 3 (2.7) | 0.192 | 0 (0.0) | 1 (0.9) | 0.225 |
| Anemia | 616 | 153 (31.1) | 48 (38.7) | 0.106 | 21 (4.3) | 19 (15.3) | < 0.001 |
| Thrombocytopenia | 616 | 63 (12.8) | 34 (27.4) | < 0.001 | 13 (2.6) | 11 (8.9) | 0.003 |
| Allergic reaction | 622 | 1 (0.2) | 0 (0.0) | 1.000 | 0 (0.0) | 0 (0.0) | 1.000 |
Values are presented as number (%).
ADE = adverse drug event, eGFR = estimated glomerular filtration rate.