Table 3.

Pharmacokinetics of vancomycin in pediatric patients with central nervous system infection

Study number	Study place	Number of patients	Age	Dosage of VCM	Concentration in CSF	CSF/serum (%)	Reference, first author (year)
1	USA	6	11 years (mean)	10–20 mg/kg, every 6-12 h	2.48 (mean)	0.77–18 (rang)	Laney Jorgenson (2007)
2	South Africa	9	15 months (mean)	15 mg/kg, every 6 h	3.3 (mean)	21 (mean)	K P Klugman (1995)
3	USA	3	26–31 weeks of gestation (range)	20 mg/kg, every 18-24 h	2.2–5.6 (range)	26–68 (rang)	Review P D Reiter (1996)
4	USA	8	4.3 years (median)	19 mg/kg, every 8 h (median)	1.07 (median)	8 (median)	Julie Autmizguine (2014)
5	Japan	1	2 years	70–100 mg/kg/d (range)	5.3 (median)	29 (median)

CSF cerebrospinal fluid, VCM vancomycin