Table 1. Characteristics of patients who received ADT, stratified by FSH.
Demographic variables | FSH | P value | |
---|---|---|---|
Low/normal (≤8 UI/mL) (N=878) | High (>8 UI/mL) (N=661) | ||
Age at ADT (years) | 73 [68, 79] | 76 [70, 83] | <0.0011 |
Year of ADT start | 2009 [2004, 2013] | 2007 [2004, 2012] | 0.0271 |
Race, n [%] | 0.1162 | ||
Black | 307 [35] | 195 [30] | |
White | 473 [54] | 377 [57] | |
Other | 40 [5] | 34 [5] | |
Unknown | 58 [7] | 55 [8] | |
BMI at ADT (kg/m2) | 30.1 (26.3, 34.2) | 29.1 (25.8, 33.2) | 0.0041 |
CCI at ADT | 0.1022 | ||
0–2 | 252 [29] | 165 [25] | |
3+ | 626 [71] | 496 [75] | |
Primary XRT or RP | 111 [13] | 98 [15] | 0.2162 |
Grade group | 0.3472 | ||
1 | 201 [23] | 144 [22] | |
2–3 | 286 [33] | 201 [30] | |
4–5 | 275 [31] | 208 [31] | |
Unknown | 116 [13] | 108 [16] | |
PSA at ADT (ng/mL) | 6.6 (2.5, 13.9) | 6.5 (2.4, 13.8) | 0.8071 |
Testosterone pre-ADT | 0.6222 | ||
<30 ng/mL | 183 [21] | 136 [21] | |
30–299 ng/mL | 203 [23] | 138 [21] | |
≥300 ng/mL | 182 [21] | 152 [23] | |
Missing | 310 [35] | 235 [36] | |
Chemo before ADT | 0.0532 | ||
Never | 753 [86] | 579 [88] | |
Before ADT | 18 [2] | 22 [3] | |
After ADT | 107 [12] | 60 [9] | |
Months from FSH to ADT | 8.4 (3.0, 15.9) | 7.9 (3.2, 14.6) | 0.1991 |
CRPC | 231 [26] | 177 [27] | 0.8372 |
Dead | 381 [43] | 337 [51] | 0.0032 |
Data are shown as median (Q1, Q3) or n [%]. 1, Wilcoxon; 2, Chi-Square. ADT, androgen deprivation therapy; FSH, follicle-stimulating hormone; BMI, body mass index; CCI, Charlson Comorbidity Index; XRT, radiation therapy; RP, radical prostatectomy; PSA, prostatic-specific antigen; CRPC, castration-resistant prostate cancer.