Fig. 1.

Summary plots of proof-of-principle FDA-approved drug screen for single and metformin drug combinations that delay Aβ-mediated paralysis. Percent change in paralysis relative to untreated animals for 633 drug treatments, alone (A) and combined with 25 mM metformin (B). Drug treatments ranked by percent change in paralysis for single and drug combination separately. Black circle = no change in paralysis. Blue circle = average paralysis delay produced by metformin alone (20% delay) averaged across all experiments. Plots generated using RCircos [152]