Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Nov 13;13:19779. doi: 10.1038/s41598-023-46076-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Genome-wide scans of iHS and Rsb-based extended haplotype homozygosity in Colombia. Panel (a) presents a Manhattan plot of the iHS −log10(p) in Colombia. The dashed black line demarks a fixed significance threshold of −log10(p) = 4. There were no signals supported by a minimum of 3 single-nucleotide polymorphisms (SNPs) above the threshold. Panels (b)–(e) present Manhattan plots of the Rsb −log10(p) for the given populations. The dashed black lines demark a fixed significance threshold of −log10(p) = 5: signals supported by a minimum of 3 single-nucleotide polymorphisms (SNPs) above the threshold within 10 kb of one another are demarked with vertical dashed grey lines and numbered. Signals associated with extended haplotypes in Colombia and their putative genetic drivers include: pvmsp1 (PVP01_0728900) in region 9 in the Brazilian comparison (panel b); 1-acyl-sn-glycerol-3-phosphate acyltransferase (PVP01_1262700) in region 10 in the Peruvian comparison (panel c); pyridoxine biosynthesis protein PDX2 (PVP01_0916800) in region 4 in the Thai comparison (panel d); a conserved Plasmodium protein with unknown function (PVP01_1115800) in region 5 (panel d); an oligomeric Golgi complex subunit 4 protein (PVP01_1133300) in region 6 (panel d); 6-cysteine proteins P12 (PVP01_1136400) and P47 (PVP01_1208000) in regions 7 and 8 (panel d); a metacaspase-2 (PVP01_1268600) in region 9 (panel d); and a PIMMS43 protein (PVP01_1129500) in region 3 in the Indonesian comparison (panel e). Further details are provided in Supplementary Table 4.