Fig. 7.

Validation with independent cohorts (rat and human). A Venn diagram showed significant intersections of our DEGs with independent rat liver aging data (PRJNA516151). B Expression of the 1474 intersected genes in PRJNA516151 revealed their trends in the aging process. C Venn diagram showed a significant intersection of our DEGs with independent human liver aging data (GSE183915). D Expression of the 235 intersected genes in GSE183915 revealed their trends in the aging process. E, F Top 10 enriched functions of the up-regulated and down-regulated genes in GSE183915