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Validated genes from the driver cluster 14
| Gene | Differential expression analysis | ||||
|---|---|---|---|---|---|
| Own data | GSE183915 (human) | PRJNA516151 (rat) | Human protein atlas (https://proteinatlas.org/) | ||
| A vs Y | A vs Y | 24 vs 6 | Tissue specificity | FDA approved? | |
| PCSK9 | UP | UP | UP | Tissue enriched (liver) | Yes |
| DPP4 | UP | UP | UP | Tissue enhanced (not liver) | Yes |
| ACLY | UP | UP | UP | Low tissue specificity | Yes |
| SC5D | UP | UP | UP | Tissue enhanced (liver) | No |
| TMEM30B | UP | UP | UP | Low tissue specificity | No |
| TMEM64 | UP | UP | UP | Tissue enhanced (not liver) | No |
