Table 3.
Association analysis for the risk HLA-DQ haplotypes of CS incidence.
| Haplotype | Cardiac sarcoidosis (n = 68) | Control (n = 311) | P_adj |
|---|---|---|---|
| DQA1*03:03/DQB1*06:01 | 16 (23%) | 13 (4.2%) | 1.5E-04 * |
| DQA1*01:03/DQB1*04:01 | 12 (17%) | 9 (2.9%) | 2.3E-03 * |
| DQA1*01:03/DQB1*06:01 | 38 (55%) | 105 (34%) | n.s |
| DQA1*01:01/DQB1*05:01 | 1 (1.5%) | 28 (9.0%) | n.s |
| DQA1*03:02/DQB1*06:01 | 10 (14%) | 21 (6.8%) | n.s |
| DQA1*05:05/DQB1*06:02 | 2 (2.9%) | 1 (0.3%) | n.s |
| DQA1*01:03/DQB1*03:03 | 10 (14%) | 24 (7.7%) | n.s |
| DQA1*03:03/DQB1*03:02 | 4 (5.9%) | 7 (2.3%) | n.s |
| DQA1*03:03/DQB1*04:01 | 21 (31%) | 68 (22%) | n.s |
| DQA1*01:03/DQB1*03:01 | 5 (7.4%) | 11 (3.5%) | n.s |
A total of 67 HLA-DQ haplotypes detected in the group with patients suffering from CS, ordered by P values; the results of the top 10 haplotypes are shown.
n.s. no significant difference.
*Significance after the correction for multiple testing (Bonferroni correction); P_adj. < 0.05.