Table 7.
Association analysis between the HLA-DQ haplotype, DQA1*05:0X/DQB1*03:01, and clinical phenotypes.
| With DQA1*05:0X/DQB1*03:01 (n = 10) | Without DQA1*05:0X/DQB1*03:01 (n = 58) | P | |
|---|---|---|---|
| Clinical characteristics | |||
| Age of onset (years) | 61 [56–66] | 62 [53–70] | 0.75 |
| Gender (female) | 6 (60%) | 37 (64%) | 1.00 |
| Clinical phenotypes | |||
| CAVB | 4 (40%) | 26 (45%) | 1.00 |
| VT or VF | 4 (40%) | 21 (36%) | 1.00 |
| Sustained VT or VF | 2 (20%) | 15 (26%) | 1.00 |
| LVEF (%) | 40 [29–46] | 47 [36–60] | 0.099 |
| Low LVEF | 9 (90%) | 32 (55%) | 0.043 * |
| Cardiac device implantation | 9 (90%) | 40 (69%) | 0.26 |
| Successful corticosteroid therapy | 1 (11%) | 20 (43%) | 0.13 |
CAVB complete atrioventricular block, VT ventricular tachycardia, VF ventricular fibrillation, LVEF left ventricular ejection fraction, Low LVEF the patients with LVEF < 50% in the echocardiography at the enrolment.
*p < 0.05.