Fig. 5.

Long-term MR does not improve lifespan when started in adult mice. Survival of adult mice started on MetR at 7–12 months of age with a median and mean start time of 9 months. Start time and range indicated by black arrow and bracket. Males (A, B) and females (C, D), wt (A, C), and MsrA-KO (B, D). All groups were 22–34 mice. Kaplan-Meyer survival curves with log-ranked Mantel-Cox test. Group sizes in Table 1