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. 2023 Nov 13;13:19729. doi: 10.1038/s41598-023-45337-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Kaplan–Meier analysis of the time-to-treatment failure between 1G, 2G, and 3G EGFR-TKIs. Patients in the micro-EGFR T790M-positive group (a) and micro-EGFR T790M-negative group (b). Patients with EGFR exon 19 deletion in the (c) micro-EGFR T790M-positive and (d) -negative groups, and patients with EGFR L858R mutation in the (e) micro-EGFR T790M-positive and (f) -negative groups. TTF time-to-treatment failure, CI confidence interval, 1G first-generation, 2G second-generation, 3G third generation, EGFR-TKIs epidermal growth factor receptor-kinase inhibitors.