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. 2023 Oct 6;45(5):2769–2783. doi: 10.1007/s11357-023-00935-x

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© The Author(s), under exclusive licence to American Aging Association 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

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Fig. 1 — Age is one of the greatest risk factors for nearly every chronic condition. Rapamycin is the most repeatable and effective pharmacological approaches to extend lifespan and delay or treat many age-related pathologies in diverse model systems. A critical translational gap in knowledge is whether rapamycin or rapamycin analogs (rapalogs) can safely maintain or improve healthy aging in humans. CVD, cardiovascular disease; T2DM, type 2 diabetes mellitus; ADRD, Alzheimer’s disease and related dementias. Figure adapted from Kaeberlein et al. [3]