Table 1.
Top five canonical pathways
| Pathway name | p value | Overlap | |
|---|---|---|---|
| Overall data | Synaptogenesis signaling pathway | 1.12E − 36 | 41.6% 132/317 |
| Spliceosomal cycle | 1.91E − 24 | 77.6% 38/49 | |
| Androgen signaling | 3.49E − 24 | 45.0% 76/169 | |
| Huntington’s disease signaling | 5.89E − 20 | 34.3% 97/283 | |
| 14–3-3-mediated signaling | 1.91E − 18 | 44.9% 57/127 | |
| Mitochondrial data set | Mitochondrial dysfunction | 1.34E − 15 | 8.8% 15/171 |
| Sirtuin signaling pathway | 3.46E − 12 | 5.1% 15/292 | |
| Oxidative phosphorylation | 6.90E − 11 | 9.0% 10/111 | |
| Xenobiotic metabolism AHR signaling pathway | 4.36E − 05 | 5.7% 5/87 | |
| Geranylgeranyl diphosphate biosynthesis I (via mevalonate) | 6.63E − 05 | 16.7% 3/18 |