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. 2023 Oct 31;14:1274431. doi: 10.3389/fimmu.2023.1274431

Table 1.

Characteristics of patients at baseline.

Clinical characteristics GC patients (n=77)
n (%)
Cohort 1 (n=41)
n (%)
Cohort 2 (n=36)
n (%)
P
Gender male 53 (68.831%) 26 (63.415%) 27 (75.000%) 0.273
female 24 (31.169%) 15 (36.585%) 9 (25.000%)
Age <60 41 (53.247%) 24 (58.537%) 17 (47.222%) 0.321
≥60 36 (46.753%) 17 (41.463%) 19 (52.778%)
ECOG score ≤2 63 (81.818%) 34 (82.927%) 29 (80.556%) 0.788
>2 14 (18.182%) 7 (17.073%) 7 (19.444%)
TNM stage II 22 (28.571%) 7 (17.073%) 15 (41.667%) 0.017
III-IV 55 (71.429%) 34 (82.927%) 21 (58.333%)
Surgery history Yes 46 (59.740%) 18 (43.902%) 28 (77.778%) 0.002
No 31 (40.260%) 23 (56.098%) 8 (22.222%)
Smoked Yes 27 (35.065%) 15 (36.585%) 12 (33.333%) 0.765
No 50 (64.935%) 26 (63.415%) 24 (66.667%)
family cancer history Yes 14 (18.182%) 6 (14.634%) 8 (22.222%) 0.389
No 63 (81.818%) 35 (85.366%) 28 (77.778%)
other chronic disease Yes 20 (25.974%) 10 (24.390%) 10 (27.778%) 0.735
No 57 (74.026%) 31 (75.610%) 26 (72.222%)
mPFS (month) median 8.87 10.67 8.1 0.003
mOS (month) median 14.83 15.7 10.83 0.021
IL-2 median[Q1, Q3] 1.740[1.210,2.590] 1.960[1.420,2.600] 1.490[1.110,2.260] 0.213
IL-4 median[Q1, Q3] 1.990[0.910,3.310] 2.370[1.020,3.310] 1.930[0.800,3.080] 0.444
IL-6 median[Q1, Q3] 6.100[3.970,14.190] 12.060[5.020,18.060] 4.850[2.980,8.280] <0.001
IL-10 median[Q1, Q3] 2.690[1.870,3.790] 2.860[1.870,3.840] 2.650[1.890,3.650] 0.748
TNF-α median[Q1, Q3] 1.940[1.300,2.700] 1.870[1.470,2.550] 2.230[1.230,2.910] 0.537
IFN-γ median[Q1, Q3] 2.060[1.460,2.590] 2.110[1.500,2.560] 1.940[1.460,2.620] 0.736
IL-17A median[Q1, Q3] 5.680[2.900,9.260] 5.680[2.340,9.890] 5.720[3.190,8.910] 0.779
TLC median[Q1, Q3] 1.320[1.040,1.700] 1.310[1.000,1.790] 1.370[1.200,1.690] 0.721
NLR median[Q1, Q3] 2.338[1.571,3.444] 2.600[1.692,4.500] 2.338[1.571,2.628] 0.234
PLR median[Q1, Q3] 149.231[109.924,209.375] 149.231[109.924,205.833] 149.693[114.557,223.171] 0.732
LMR median[Q1, Q3] 3.478[2.370,4.238] 3.462[2.167,4.238] 3.714[2.726,3.953] 0.713

Eastern Cooperative Oncology Group Performance Status (ECOG PS). P < 0.05 was considered statistically significant and shown in bold type.