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. 2023 Sep 13;29(22):4596–4605. doi: 10.1158/1078-0432.CCR-23-1578

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©2023 The Authors; Published by the American Association for Cancer Research

This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license.

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Figure 3. ctDNA monitoring on chemoIO identifies patients with poorer outcomes on IO maintenance. Comparing C4 to C1 ctDNA levels, Kaplan–Meier analysis demonstrates favorable outcomes in patients with (A) any decrease and (B) full ctDNA clearance. In multivariate analysis using a Cox model adjusting for clinical and genomic features, ctDNA change remains a statistically significant prognostic factor (Supplementary Fig. S3). — ctDNA monitoring on chemoIO identifies patients with poorer outcomes on IO maintenance. Comparing C4 to C1 ctDNA levels, Kaplan–Meier analysis demonstrates favorable outcomes in patients with (A) any decrease and (B) full ctDNA clearance. In multivariate analysis using a Cox model adjusting for clinical and genomic features, ctDNA change remains a statistically significant prognostic factor (Supplementary Fig. S3).