Table 3.
Factors associated with neonatal thrombocytopenia <50 × 109/L in 171 newborns
| Neonatal thrombocytopenia (platelet count <50 × 109/L) |
Univariable analysis |
Multivariable analysis |
|||||
|---|---|---|---|---|---|---|---|
| Total(n = 136) | No(n = 117) | Yes(n = 19) | Unadjusted odds ratio [95% CI] | P value∗ | Adjusted odds ratio [95% CI] | P value† | |
| Maternal platelet count at delivery < 50 × 109/L (n=127/109/18) | 8 (6.3) | 6 (5.5) | 2 (11.1) | 2.15 [0.40-11.57] | .37 | ||
| Maternal platelet count < 50 × 109/L within 3 months before delivery | 44 (32.4) | 33 (28.2) | 11 (57.9) | 3.5 [1.29-9.47] | .01 | 4.07 [1.41-11.73] | .009 |
| Disease status at pregnancy diagnosis | .14 | ||||||
| CR | 62 (45.6) | 57 (48.7) | 5 (26.3) | 1 (ref) | |||
| R | 59 (43.4) | 49 (41.9) | 10 (52.6) | 2.33 [0.74-7.27] | |||
| NR | 15 (11.0) | 11 (9.4) | 4 (21.1) | 4.15 [0.96-17.93] | |||
| Disease status worsening between M0 and M9 | 65 (47.8) | 52 (44.4) | 13 (68.4) | 2.71 [0.96-7.61] | .06 | ||
| Previous history of neonatal thrombocytopenia | 20 (14.7) | 13 (11.1) | 7 (36.8) | 4.67 [1.56-13.96] | .006 | 5.55 [1.72-17.89] | .004 |
| Previous splenectomy | 16 (11.8) | 13 (11.1) | 3 (15.8) | 1.50 [0.38-5.85] | .56 | ||
| Treatment to prepare delivery IVIg and/or CT |
58 (42.7) | 47 (40.2) | 11 (57.9) | 2.05 [0.77-5.47] | .15 | ||
The results are given as number of events (%).
CI, confidence interval; CR, complete response; CT, corticosteroids; IVIg, intravenous immunoglobulin; NR, nonresponse; R, response; ref, reference category.
∗
Wald test from univariable logistic regression.
†
Multivariable logistic regression model, adjusted for maternal platelet count and previous history of neonatal thrombocytopenia.