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. 2023 Apr 7;142(6):509–518. doi: 10.1182/blood.2022018071

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© 2023 by The American Society of Hematology. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0), permitting only noncommercial, nonderivative use with attribution. All other rights reserved.

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Figure 1. — Hematopoietic stem cell markers and their potential signaling interactions governing their biology. A schematic diagram of potential signaling pathways downstream of key markers expressed on CD34⁺(CD38/CD45RA)^–EPCR⁺ HSCs (which are also CD49f⁺ and CD90⁺/⁻) upon interacting with their potential ligands in the niche. This highly HSC-enriched population highly expresses CD33, CD93, CD117, CD133, and CD143.³⁰ We hypothesize that these cells may also express GPRC5C and CD370 as well as PAR1 and ATR1 (to convey the EPCR/APC/PAR1 and CD143/Ang-/ATR1 signaling, respectively).