Table 1.
Significant MR analysis results between gut microbiota and SAT generation.
| GWAS ID | Bacterial taxa (exposure) | MR method | No. of SNP | F-statistic | OR | 95% CI | p-value |
|---|---|---|---|---|---|---|---|
| GCST90016912 | Betaproteobacteria | MR Egger | 12 | 21.664 | 0.93 | 0.66–1.30 | 0.661 |
| Weighted median | 0.94 | 0.84–1.05 | 0.264 | ||||
| IVW | 0.88 | 0.80–0.96 | 0.005 | ||||
| Simple mode | 0.96 | 0.81–1.14 | 0.633 | ||||
| Weighted mode | 0.96 | 0.83–1.12 | 0.621 | ||||
| GCST90017046 | Rikenellaceae RC9 gut group | MR Egger | 11 | 21.171 | 1.14 | 0.90–1.44 | 0.316 |
| Weighted median | 1.05 | 1.00–1.11 | 0.051 | ||||
| IVW | 1.05 | 1.02–1.10 | 0.005 | ||||
| Simple mode | 1.07 | 0.98–1.17 | 0.139 | ||||
| Weighted mode | 1.07 | 0.99–1.16 | 0.122 | ||||
| GCST90017053 | Ruminococcaceae UCG002 | MR Egger | 22 | 21.413 | 0.93 | 0.81–1.08 | 0.354 |
| Weighted median | 0.93 | 0.86–1.01 | 0.869 | ||||
| IVW | 0.94 | 0.89–0.99 | 0.017 | ||||
| Simple mode | 0.91 | 0.77–1.06 | 0.224 | ||||
| Weighted mode | 0.90 | 0.78–1.05 | 0.192 | ||||
| GCST90017000 | Eubacterium hallii group | MR Egger | 16 | 20.975 | 1.14 | 0.99–1.31 | 0.088 |
| Weighted median | 1.08 | 0.99–1.17 | 0.102 | ||||
| IVW | 1.08 | 1.01–1.15 | 0.028 | ||||
| Simple mode | 1.10 | 0.95–1.28 | 0.235 | ||||
| Weighted mode | 1.12 | 0.97–1.29 | 0.137 | ||||
| GCST90016920 | Methanobacteria | MR Egger | 10 | 22.085 | 0.95 | 0.79–1.14 | 0.605 |
| Weighted median | 0.95 | 0.90–1.00 | 0.042 | ||||
| IVW | 0.96 | 0.92–1.00 | 0.029 | ||||
| Simple mode | 0.94 | 0.85–1.03 | 0.188 | ||||
| Weighted mode | 0.94 | 0.85–1.03 | 0.214 | ||||
| GCST90016942 | Methanobacteriaceae | MR Egger | 10 | 22.085 | 0.95 | 0.79–1.14 | 0.605 |
| Weighted median | 0.95 | 0.90–1.00 | 0.048 | ||||
| IVW | 0.96 | 0.92–1.00 | 0.029 | ||||
| Simple mode | 0.94 | 0.85–1.03 | 0.189 | ||||
| Weighted mode | 0.94 | 0.85–1.03 | 0.224 | ||||
| GCST90016945 | Peptococcaceae | MR Egger | 9 | 22.762 | 1.15 | 0.95–1.39 | 0.189 |
| Weighted median | 1.13 | 1.03–1.23 | 0.006 | ||||
| IVW | 1.08 | 1.01–1.17 | 0.034 | ||||
| Simple mode | 1.14 | 0.99–1.32 | 0.104 | ||||
| Weighted mode | 1.15 | 1.03–1.29 | 0.041 | ||||
| GCST90017042 | Peptococcus | MR Egger | 12 | 22.565 | 1.09 | 1.91–1.31 | 0.363 |
| Weighted median | 1.03 | 0.97–1.09 | 0.348 | ||||
| IVW | 1.05 | 1.00–1.10 | 0.047 | ||||
| Simple mode | 1.02 | 0.93–1.12 | 0.703 | ||||
| Weighted mode | 1.02 | 0.92–1.12 | 0.718 | ||||
| GCST90017094 | Burkholderiales | MR Egger | 11 | 22.139 | 0.92 | 0.70–1.22 | 0.591 |
| Weighted median | 0.92 | 0.82–1.03 | 0.130 | ||||
| IVW | 0.90 | 0.83–0.98 | 0.012 | ||||
| Simple mode | 0.94 | 0.78–1.12 | 0.482 | ||||
| Weighted mode | 0.95 | 0.79–1.14 | 0.581 | ||||
| GCST90017102 | Methanobacteriales | MR Egger | 10 | 22.085 | 0.95 | 0.79–1.14 | 0.605 |
| Weighted median | 0.95 | 0.89–1.00 | 0.048 | ||||
| IVW | 0.96 | 0.92–1.00 | 0.029 | ||||
| Simple mode | 0.94 | 0.85–1.03 | 0.194 | ||||
| Weighted mode | 0.94 | 0.85–1.03 | 0.218 |