Table 2.

Significant MR analysis results between gut microbiota and VAT generation.

GWAS ID	Bacterial taxa (exposure)	MR method	No. of SNP	F-statistic	OR	95% CI	p-value
GCST90017111	Bacteroidetes	MR Egger	12	21.893	1.03	0.89–1.20	0.700
		Weighted median			1.09	0.99–1.21	0.082
		IVW			1.09	1.01–1.17	0.018
		Simple mode			1.17	0.99–1.40	0.100
		Weighted mode			1.12	0.98–1.28	0.134
GCST90016999	Eubacterium fissicatena group	MR Egger	9	21.157	0.93	0.75–1.16	0.533
		Weighted median			0.94	0.89–1.00	0.037
		IVW			0.95	0.91–0.99	0.019
		Simple mode			0.93	0.85–1.01	0.124
		Weighted mode			0.93	0.85–1.02	0.148
GCST90017074	Turicibacter	MR Egger	10	22.415	1.00	0.78–1.27	0.973
		Weighted median			0.94	0.87–1.01	0.070
		IVW			0.93	0.88–0.99	0.022
		Simple mode			0.92	0.82–1.04	0.215
		Weighted mode			0.96	0.86–1.08	0.523
GCST90016986	Defluviitaleaceae UCG011	MR Egger	9	22.870	0.85	0.71–1.03	0.139
		Weighted median			0.91	0.84–0.98	0.014
		IVW			0.94	0.89–0.99	0.024
		Simple mode			0.90	0.80–1.01	0.114
		Weighted mode			0.90	0.80–1.01	0.101
GCST90016912	Betaproteobacteria	MR Egger	12	21.664	0.85	0.62–1.17	0.334
		Weighted median			0.93	0.84–1.03	0.190
		IVW			0.91	0.83–0.99	0.030
		Simple mode			0.99	0.83–1.17	0.872
		Weighted mode			0.98	0.83–1.16	0.820
GCST90016998	Eubacterium eligens group	MR Egger	8	20.687	0.84	0.59–1.19	0.370
		Weighted median			1.15	1.03–1.28	0.010
		IVW			1.09	1.01–1.19	0.037
		Simple mode			1.16	0.98–1.38	0.125
		Weighted mode			1.16	0.98–1.38	0.124
GCST90016964	Alloprevotella	MR Egger	6	21.198	0.92	0.60–1.40	0.709
		Weighted median			1.05	0.98–1.11	0.145
		IVW			1.05	1.00–1.10	0.038
		Simple mode			1.04	0.95–1.14	0.403
		Weighted mode			1.04	0.96–1.13	0.342
GCST90017043	Phascolarctobacter-ium	MR Egger	9	22.007	0.86	0.63–1.18	0.389
		Weighted median			1.06	0.97–1.16	0.214
		IVW			1.07	1.00–1.15	0.042
		Simple mode			1.06	0.91–1.22	0.488
		Weighted mode			1.05	0.91–1.21	0.490