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. 2023 Nov 14;11(6):e01151. doi: 10.1002/prp2.1151

FIGURE 2.

FIGURE 2

Goodness‐of‐fit plot of the QTc model. The solid black line and gray shaded region denote the model‐predicted mean (90% CI) ΔΔQTcF, which is calculated from the equation ΔΔQTcF ≈ 0.61 + 0.0025 × GSK'254 concentration. The red filled circles with error bars denote the estimated mean ΔΔQTcF with 90% CI at the associated median plasma concentration within each GSK'254 concentration decile. The blue open circle with error bars denotes the mean ΔΔQTcF with 90% CI for placebo. The horizontal red line with notches shows the range of GSK'254 concentrations divided into deciles. The black dashed line denotes the 10‐ms threshold. QTc, corrected QT; ΔΔQTcF, placebo‐adjusted change from baseline in QT interval corrected using Fridericia's formula.