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. 2015 Mar 20;2015(3):CD003988. doi: 10.1002/14651858.CD003988.pub2

3. Sensitivity analysis.

Studya Comparison groups N Postpartum initiation Lactationb Breast milkc Infant growth
Levonorgestrel‐releasing intrauterine system (LNG‐IUS)
Shaamash 2005
  • LNG‐IUS (20 μg)

  • CuT 380A IUD

320 6 to 8 weeks NSd:
 full BF (Analysis 2.3) ‐‐‐ NSd:
weight (Analysis 2.1) and length Analysis 2.2)
Stuart 2014 LNG‐IUS (20 μg) insertion times
  • ≤ 48 hours

  • 4 to 8 weeks

35 48 hours vs
 4 to 8 weeks NS:
 any BF (Analysis 3.1) ‐‐‐ ‐‐‐
Etonogestrel‐releasing (ETG) implant: early versus standard insertion
Brito 2009
  • ETG implant, early insertion (1 to 2 days)

  • No method for 6 weeks, then DMPA

40 24 to 48 hours vs 6 weeks NS:
 full BF (Analysis 4.1) ‐‐‐ Weight:
 6 weeks, ETG implant > no method (Analysis 4.2); 12 weeks, DMPA > ETG implant (Analysis 5.2)
Gurtcheff 2011 ETG implant, postpartum insertion
  • Early (1 to 3 days)

  • Standard (4 to 8 weeks)

65 1 to 3 days vs 4 to 8 weeks NS:
 failure (Analysis 6.1); full BF (Analysis 6.4); any BF (Analysis 6.5) NS:
 lactogenesis II (Analysis 6.2); creamatocrit (Analysis 6.3) ‐‐‐
Combined (COC) versus progestin‐only (POP) oral contraceptive
WHO 1984
  • COC levonorgestrel + EE

  • POP norgestrel

171 6 weeks ‐‐‐ Volume:
 COC < POP (Analysis 7.1) NSd:
 weight (Analysis 8.3)
Espey 2012
  • COC norethindrone + EE

  • POP norethindrone

179 2 weeks NS:
 BF (Analysis 8.3) ‐‐‐ NS:
 weight (Analysis 8.1) and length (Analysis 8.2)

aIncludes studies with moderate‐quality evidence (Table 9) and sufficient outcome data (Table 10). Direction of significant differences shown (reported or analyzed); NS = not significantly different.
 bInitiation; failure; breastfeeding (BF) full, any, or discontinuation.
 cTime to lactogenesis II; milk volume or composition.
 dReported; insufficient data for analysis in this review.