Table 2. Time-to-Event Outcomes Comparison Between Randomized Diuretic Treatment Groups Stratified by De Novo vs Worsening Chronic Heart Failure (WHF).
| Outcomes | De novo | WHF | P for interactionc | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Torsemide events (rate per 100 PY)a | Furosemide events (rate per 100 PY)a | HR/RR (T vs F)b | P value | Torsemide rate (rate per 100 PY)a | Furosemide rate (rate per 100 PY)a | HR/RR (T vs F)b | P value | ||
| All-cause mortality over 12 mo a , b | |||||||||
| Overall | 27 (7.4) | 38 (10.9) | 0.70 (0.4-1.14) | .15 | 212 (26.8) | 196 (24.0) | 1.08 (0.89-1.32) | .42 | .10 |
| EF level, % | |||||||||
| ≤40 | 13 (5.4) | 25 (10.9) | 0.50 (0.26-0.99) | .04 | 140 (27.7) | 122 (24.4) | 1.10 (0.86-1.41) | .45 | .03 |
| >40 | 11 (10.7) | 8 (8.2) | 1.22 (0.49-3.07) | .67 | 53 (23.0) | 56 (23.6) | 0.93 (0.63-1.36) | .71 | .59 |
| All-cause mortality or rehospitalization over 12 mo | |||||||||
| Overall | 137 (61.4) | 156 (73) | 0.86 (0.68-1.08) | .20 | 535 (114.8) | 545 (121.9) | 0.94 (0.83-1.06) | .33 | .49 |
| EF level, % | |||||||||
| ≤40 | 84 (55.2) | 89 (60.9) | 0.93 (0.69-1.25) | .63 | 345 (115.7) | 333(121.9) | 0.94 (0.81-1.10) | .47 | .92 |
| >40 | 45 (76.6) | 50 (93.1) | 0.87 (0.58-1.30) | .49 | 151 (110.9) | 160 (124.2) | 0.90 (0.72-1.13) | .35 | .88 |
| All-cause first rehospitalization over 12 mo | |||||||||
| Overall | 121 (54.8) | 132 (63.9) | 0.88 (0.69-1.13) | .32 | 411 (94.5) | 442 (103.9) | 0.91 (0.79-1.04) | .17 | .83 |
| EF level, % | |||||||||
| ≤40 | 74 (49.0) | 72 (51.0) | 0.99 (0.72-1.8) | .97 | 264 (95.0) | 267 (102.1) | 0.93 (0.78-1.10) | .38 | .71 |
| >40 | 39 (67.6) | 46 (88.4) | 0.81 (0.53-1.25) | .35 | 118 (92.0) | 134 (110.2) | 0.85 (0.66-1.09) | .21 | .85 |
Abbreviations: EF, ejection fraction; F, furosemide; HR, hazard ratio; PY, patient-years; RR, rate ratio; T, torsemide.
For each cell, for all-cause mortality and all-cause mortality or rehospitalization over 12 months, the numbers displayed are number of events (Kaplan-Meier failure rate %) event rate per 100 PY of follow-up. For all-cause first rehospitalization over 12 months, the numbers displayed are number of events (cumulative incidence rate %) event rate per 100 PY of follow-up.
For all-cause mortality and all-cause mortality/re-hospitalization over 12 months, HR, 95% CI, and P value are based on a Cox proportional hazards regression model. For all-cause first primary rehospitalization over 12 months, HR, 95% CI, and P value is based on a Cox proportional hazards model where death is considered as competing risk and is censored at time of death. For the overall patient model, the covariates are diuretic treatment (T, F), HF type, age, sex, baseline EF categories (≤40%, 41%-49%, ≥50%, unknown). For each stratified analysis by EF level, the covariates are diuretic treatment, HF type, age, sex, and continuous baseline EF.
The interaction P values are between diuretic treatment and HF type for overall patients and each EF level.