Table 1. Compounds 11 and 13 Display Enhanced Antibacterial Activity against S. aureus and S. epidermidis.
| minimum
inhibitory concentration (μg/mL) |
|||||||
|---|---|---|---|---|---|---|---|
| strain | 1771 | 9 | 10 | 11 | 12 | 13 | 14 |
| S. aureus | |||||||
| LAC | 8 | 32–64 | 64 | 4 | 8 | 0.5 | >64 |
| MW2 | 8 | 64 | 64 | 2 | 8 | 0.5 | >64 |
| Newman | 4–8 | 32 | 64 | 2 | 8 | 0.5 | >64 |
| SH1000 | 4–8 | 32 | 64 | 2 | 8 | 0.5 | >64 |
| MRSA252 | 8 | 64 | 64 | 4 | 16 | 1 | >64 |
| TW20 | 8 | 32 | 64 | 2 | 8 | 0.5 | >64 |
| Mu50 | 4–8 | 64 | 64 | 2 | 4–8 | 0.5 | >64 |
| Mu3 | 8–16 | 64 | 64 | 2 | 8 | 0.5 | >64 |
| EMRSA-15 | 8–16 | 64 | 32–64 | 2 | 8 | 0.5 | >64 |
| S. epidermidis | |||||||
| RP62A | 8–16 | 32 | 64 | 2–4 | 4–8 | 0.5 | >64 |
| 311 | 8–16 | 64 | 32–64 | 2 | 4–8 | 0.5 | >64 |
| 771 | 8–16 | 64 | 32–64 | 2 | 4–8 | 0.5 | >64 |
| 780 | 8–16 | 32 | 32–64 | 4 | 4–8 | 0.5–1 | >64 |
| 319 | 8–16 | 64 | 64 | 2 | 4–8 | 1 | >64 |
| 322 | 16 | 64 | 64 | 4 | 8 | 0.5 | >64 |
| 305 | 8–16 | 64 | 32–64 | 2–4 | 8 | 0.5–1 | >64 |