Table 3. (a,b) Impact of LtaS Deletion and Overexpression on the Susceptibility of S. aureus to 1771 and 13.
| (a) | ||
|---|---|---|
| strain | MIC (μg/mL) |
|
| 1771 | 13 | |
| 8325-4 (wild type) | 16 | 0.5–1 |
| 8325-4 clpX knockout mutant | 8 | 0.25 |
| 8325-4 clpX knockout and ltaS382STOP mutant | 8 | 0.25 |
| SA564 (wild type) | 16 | 0.25 |
| SA564 clpX knockout mutant | 16 | 0.25 |
| SA564clpX knockout and ltaSH476Q mutant | 16 | 0.25 |
| JE2 (wild type) | 16 | 0.5 |
| JE2 clpXI265E mutant | 8 | 0.25 |
| JE2 clpXI265E and ltaS339STOP mutant | 16 | 0.5 |
| 8325-4 (wild type) | 8 | 0.5 |
| M0674N (ltaS knockout mutant in 8325-4) | 8 | 0.5 |
| (b) | |||
|---|---|---|---|
| strain | Congo red | MIC (μg/mL) |
|
| 1771 | 13 | ||
| Newman | >512 | 16 | 1 |
| Newman ΔtarO | 64 | 16 | 1 |
| Newman ΔtarO pRMC2 | 64 | 16 | 1 |
| Newman ΔtarO pltaS | 256 | 16 | 1 |