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. 2023 Oct 27;6(11):1715–1723. doi: 10.1021/acsptsci.3c00171

Figure 3.

Figure 3

Schematic diagram of the experimental design. (A) HFD/F (negative control): HFD/F was given for 6 weeks with no treatment at any time. (B) Met (positive control): HFD/F was given for 6 weeks followed by metformin (100 mg/kg/day) for 3 weeks. (C) Ato (positive control): HFD/F was given for 6 weeks followed by atorvastatin 10 mg/kg/day for 3 weeks. (D) SMEE/P (preventive): SMEE (200 mg/kg/day) was administered for 3 weeks followed by HFD/F for 6 weeks. (E) SMEE/T (treatment): HFD/F was given for 6 weeks followed by SMEE (200 mg/kg/day) for 3 weeks. Comparisons were made with the negative control group at the end of week 9 for the preventive groups or with the positive and negative control groups at the end of week 12 for the treatment groups.