Table 2.

Current therapeutic approaches targeting OPCs in AD mice

Therapeutic approach	Species	Target	Description	References
Senolytic	APP/PS1 transgenic mice	Senescent OPCs	Utilizes compounds that can selectively clear senescent OPC	[18]
Rejuvenation	Hemizygous hAPP-J20 mice	Senescent OPCs	Mitigates OPC aging by overexpressing anti-aging gene KLOTHO	[209]
Promotion of cell differentiation	3×Tg-AD mice	OPC differentiation-related pathways	Promotes OPC differentiation with RXR agonist	[216]
	APP/PS1 transgenic mice		Promotes OPC differentiation with mTOR inhibitor	[15]