Table 3. Optimizations in Synthesis Procedures for Previously Reported 11C-Tracers.
| radiotracer | optimization benefits | confirmation of 11C-tracer identity | ref(s) |
|---|---|---|---|
| [11C]acetate | - higher yield | HPLC-UV with a refractive index detector | (37) |
| [11C]acetoacetate | - automated on another synthesis unit | HPLC-UV | (85) |
| - shorter synthesis time | |||
| [11C]choline | - introduction of a different sorbent for SPE | HPLC with a conductivity detector | (22) |
| - synthesis on a different module | |||
| [11C]UCB-J | - higher yield | HPLC-UV | (38) |
| - one step reaction | |||
| [11C]PBR28 | - higher yields | 1H NMR | (86) |
| - shorter reaction time | Melting point | ||
| HPLC-UV | |||
| [11C]PiB | - higher yields to serve two consecutive patients with a single preparation | HPLC-UV | (87) |
| - [11C]CO2 used as synthon | HPLC-UV | (16,88) |