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Functional domains of VDR protein and activation of VDR. A Functional domains of VDR proteins. Different domains, including NTD, DBD, and LBD, are shown. B The classic VDR signaling. The VDR-ligand complex forms a heterodimer with RXR, and the complex translocates to the nucleus. In the nucleus, the VDR-RXR heterodimer binds to VDREs located in the promoter regions of target genes, leading to the recruitment of coactivators and the initiation of gene transcription
