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. 2023 Nov 13;25:142. doi: 10.1186/s13058-023-01726-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Method overview: (1) Segment slides into different tissue types and detect mitoses. (2) Compute biomarkers from the segmentation prediction of tumor, stroma and lymphocytes and detected mitoses within tumor regions. LTR: lymphocyte-tumor ratio, cTILs: computational tumor infiltrating lymphocytes score, ITR: inflamed tumor ratio (proportion of tumor close to lymphocytes), MTR: mitoses-tumor ratio