Table 2.
Demographic and clinicopathologic features of the oral erythroplakia cases
| Country | Sex/age | Smoking | Alcohol use | Site | Clinical features | Incision biopsy diagnosis/ Diagnosis after excision | Size in mm | Symptoms | Treatment | Follow-up in months | Recurrence of OE | Malignant transformation | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Finland | F/56 | No | N/av | BM | Well-defined | SD/SD | N/av | Tenderness, especially when eating spicy food and citruses | SE | 180 | No | No |
| 2 | Finland | F/81 | No | Yes, “very little” | BM | Mostly well-defined | (1) Severe inflammation, epithelial atypia and ulceration, (2) Lichenoid inflammation, severe inflammation, (3) Inflammatory atypia x 3, active inflammation x 2, eosinophilia, severe inflammation/MoD (HPV, p16 negative | 17 × 33 | Tenderness, pain when eating and on palpation | SE | 56 | No | No |
| 3 | Finland | F/78 | Never | No | BM | Well-defined, situated slightly below the adjacent mucosa | CIS/CIS | 5 × 5 | Intermittent pain | SE | 63 | No | No |
| 4 | Finland | F/62 | Never | Yes | G | Well-defined, situated slightly below the adjacent mucosa | (1) Lichenoid inflammation (BM), IF negative (G), (2) Lichenoid inflammation, (3) Lichenoid inflammation and epithelial atypia x 3, (4) IF negative/n/a | 5 × 40 | No | LE | 42 | No | No |
| 5 | Italy | F/81 | No | No | BM | Well-defined | Severe dysplasia/n/a | 20 × 30 | No | LE | 36 | Yes | No |
| 6 | Sweden | F/78 | No | N/av | G | Well-defined | CIS/CIS | 20 × 30 | No | SE | 96 | Yes | No |
| 7 | Sweden | M/76 | No | Yes | HP | Well-defined, minor white areas | SD/SD | 30 | No | SE | 96 | Yes | Yes |
| 8 | Sweden | M/72 | No | Yes | BM | Well-defined, white areas around the periphery | MoD/SD | 20 × 30 | No | SE | 121 | Yes | No |
| 9 | Sweden | F/57 | Previously | N/av | G | Partly well-defined | LR/LR + MiD | 20 | No | SE | 84 | Yes | No |
| 10 | Sweden | F/54 | No | No | T | Well-defined, minor white areas around the periphery | LR/Ulceration + LR | 20 | No | SE | 24 | No | No |
| 11 | Sweden | M/91 | No | Yes | T | Well-defined | CIS/CIS | 10 | No | SE | 2 | No | No |
CIS = carcinoma in situ, LR = lichenoid reaction, MiD = mild dysplasia, MoD = moderate dysplasia, OE = oral erythroplakia, SD = severe dysplasia, BM = buccal mucosa, FOM = floor of mouth, G = gingiva, HP = hard palate, T = Tongue, SE = surgical excision, LE = laser evaporation
N/a = not applicable
N/av = information not available