Table 2.
Clinical studies of PJAC transplantation
| References | Study type | Location | Sample size | Lesion size | Follow-up | Outcome measure | Outcome | Complication related to grafts |
|---|---|---|---|---|---|---|---|---|
| Tompkins et al.(2013) [48] | Case series | Patella | 15 knees | 2.4 ± 1.2 cm2 | 28.8 months | KOOS, IKDC, Kujara, Tegner, VAS, MRI | Mean fill of defect at follow-up was 89%. |
2 lesions: graft hypertrophy 1 lesion: complete graft failure/delamination |
| Farr et al. (2014) [13] | Case series | Femoral condyle or Trochlea | 29 lesions | 2.7 ± 0.8 cm2 | 24 months | KOOS, IKDC, VAS, MRI | Improved in KOOS, IKDC, and VAS; T2-weighted scores were returning to a level approximating that of normal articular cartilage by 2 years. |
2 lesions: partial graft failure/delamination 1 lesion: partially filled defect |
| Buckwalter et al. (2014) [49] | Case series | Patella | 13 patients | 2.3 ± 1.8 cm2 | 8.2 months | KOOS, WOMAC | Improved in KOOS overall. | none |
| Grawe et al. (2017) [50] | Case series | Patella | 45 patients | 2.1 ± 1.2 cm2 | 6,12, and 24 months | MRI |
85% of patients at 12mo displayed good to moderate fill. Demonstrated progressive graft maturation over time by imaging. |
1 patient: graft displacement 2 patients: graft hypertrophy |
| Wang et al. (2018) [14] | Case series | Patella or trochlea | 30 lesions | 2.1 ± 1.2 cm2 | 3.8 years | IKDC, KOS-ADL, MAS, MRI | Improved in IKDC and KOS-ADL, no change in MAS. 69% of patients had a majority lesion fill. | none |
| Dawkins et al. (2022) [15] | Case series | Patella or trochlea | 36 knees | 2 cm2 | 33.8 months | Return to sport rate, MRI | Return to sports rate was 100%. 78% of patients had a majority defect fill. |
1 knee: Tissue delamination 1 knee: Full-thickness graft fissuring |