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. 2023 Oct 31;17:1268126. doi: 10.3389/fncel.2023.1268126

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Copyright © 2023 Mohamed, Abo Nahas, Elshaer, El-Waseef, El-Kharashi, Mohamed, Sabry, Almaimani, Almasmoum, Altamimi, Ibrahim, Alshawwa, Jaremko, Emwas and M. Saied.

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Showing intestinal mucosa in juvenile groups. (A,B) Control. (A) Showing intestinal (juvenile) mucosa formed of thin finger-like villi (V) and crypts of Lieberkühn (↑). Musculosa (M) is seen under the mucosa. (B) Showing enterocytes (E) columnar with acidophilic cytoplasm, oval basal vesicular nuclei and intact brush border (BB). Notice the goblet cells (G) and intraepithelial lymphocytes (↑). The core of the villi is formed of CT lamina propria with mononuclear cells. (C–E) Indomethacin (Model) group. (C) Showing distended villi (V) with apparently increased mononuclear inflammatory cells in their cores (*). (D) Many enterocytes (E) appear cubical with rounded deeply stained nuclei. Some villi have interrupted brush border (BB). The core of the villi is markedly vacuolated (*) and shows areas of hemorrhage (▴). (E) Some villi showed extensive mononuclear inflammatory cellular infiltration in their cores (*). H&E: (A,C) × 100, (B,D,E) × 400.