Table 1.

Review of Quantitative EEG Analyses in Angelman Syndrome.^a

Authors	Comparison Group (n)	Method	Results
Sidorov et al 33	AS (26) HCb (54)	Resting EEG • EEG power • EEG dynamics	Increased delta power Increased delta dynamics Delta power reduced with age, but did not normalize
Den Bakker et al 34	AS (28), NREM sleep (13), Wake (26) HCb (72), NREM sleep (54), wake (54)	Resting EEG • EEG power • Coherence map • Spindle detection	No difference in short-range coherence Increased long-range coherence in sleep and wake Increased delta power Decreased number and duration of sleep spindles
Frohlich et al 35	Deletion AS (37) Nondeletion AS (30) HC (48)	Resting EEG • EEG power • Peak frequency	Increased delta power (deletion > nondeletion) Decreased beta power (deletion < nondeletion)
Frohlich et al 38	AS (35)	Resting EEG • EEG power • Signal complexity (modified multiscale entropy)	Increased signal complexity in wake vs sleep EEG when controlling for delta power
Hipp et al 36	AS (45)	Resting EEG • EEG power	Increased delta power correlated to increased clinical severity and earlier onset epilepsy
Ostrowski et al 37	AS (82)	Resting EEG • EEG power	Inverse relationship between delta power and cognition, receptive and expressive communication, and fine motor skills

Abbreviations: AS, Angelman syndrome; EEG, electroencephalography; HC, healthy control; NREM, non–rapid eye movement.

^a Across all studies, there was increased delta power, and relative delta power tended to correlate to increased phenotypic severity.

^b Age-matched.