Table 4.
Structures and structural predictions of Psl biosynthetic proteins.
| Protein | UniProtKB | PDB code for structure | PDB code for structurally similar protein from DALI search | Function or predicted function | Fold or domains (residues)a | Reference |
|---|---|---|---|---|---|---|
| PslA | Q9I1N8 | 3NKL, 5W7L | Polymer polymerization, initiating GT that adds Psl repeat unit to lipid carrier | TM domain (1–147), Rossmann fold (147–273), bacterial sugar transferase (273–478) | Ray et al. (2018) | |
| PslB | Q9I1N7 | 2 × 65, 2PFW | PMI activity, GMP activity | Rossmann-like fold (9–216), left β-helix (217–368), cupin domain (369–488) | Pelissier et al. (2010) | |
| PslC | Q9I1N6 | 7SP8 | GT | GT-A fold | Maloney et al. (2022) | |
| PslD | Q9I1N5 | 2J58 | OPX | Antiparallel β-sandwich with α helix (46–134), mixed α/β fold (135–220) | Dong et al. (2006) | |
| PslE | Q9I1N4 | 7NII | PCP | TM domain (5–39, 457–484), protein kinase domain (458–662) | Yang et al. (2021) | |
| PslF | Q9I1N3 | 6KIH | GT | GT-B fold | Li et al. (2020) | |
| PslG | Q9I1N2 | 5BXA, 4ZN2 | Glycoside hydrolase | TM helix (1–31), (β/α)8 TIM barrel fold (31–359), β sandwich fold (360–442) | Baker et al. (2015), Yu et al. (2015) | |
| PslH | Q9I1N1 | 6KIH | GT-B fold | Li et al. (2020) | ||
| PslI | Q9I1N0 | 6KIH | GT-B fold | Li et al. (2020) | ||
| PslJ | Q9I1M9 | 7TPG | Wzy GT | GT-C fold | Ashraf et al. (2022) | |
| PslK | Q9I1M8 | 6NC6 | Wzx flippase | MATE-like, MurJ-like | Kuk et al. (2019) | |
| PslL | Q9I1M7 | O-acyltransferase, unknown |
a
Numbering for P. aeruginosa protein.