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. 2023 Oct 4;44(43):4508–4532. doi: 10.1093/eurheartj/ehad653

Table 11.

Echocardiographic Parameters for Assessing TR Severity Pre- and Post-TTVR

Baseline Post-TEER Post-Annular Repair Post-TTVR (Orthotopic)
Qualitative parameters
Flow convergence zone + + + +
CWD jet density/shape + + + +
Semiquantitative parameters
Color flow jet area ++ + + +
VC width (average of orthogonal views) +++ + (adding multiple jets has not been validated) +++ +++
PISA radius +++ ± (abnormal shape of proximal flow may result in overestimation) +++ +++ (for central TR)
Hepatic vein flow pattern ++ ± (abnormal RA compliance may affect specificity) ± (abnormal RA compliance may affect specificity) ± (abnormal RA compliance may affect specificity)
Quantitative parameters
PISA EROA +++ ± (abnormal shape of proximal flow may result in overestimation) + +++ (for central TR)
2D Doppler quantitative EROA ++ - + -
3D vena contracta area +++ +++ +++ +++
Regurgitant volume +++ + + +
Regurgitant fraction +++ (+)a +++ (+)a

PISA = proximal isovelocity surface area; VC = vena contracta; other abbreviations as in Tables 3 and 4.

aGiven the diastolic flow restriction by the device, diastolic stroke volume will be overestimated. Regurgitant fraction may be performed if a total RV stroke volume is obtained by other methods (ie, 3D echocardiography or cardiac magnetic resonance) and regurgitant volume is quantified by 3D VCA. + indicates the utility of the parameter with multiple plus signs indicating greater utility; − indicates no utility or significant limitations of the parameter; ± indicates possible utility.