Table 12.

Circulating Biomarkers and End-Organ Function

Biobanks	Recommended for inclusion in trials testing therapies for TR to identify and characterize the association between known and novel circulating biomarkers and procedural success and longer-term clinical outcomes
Cardiac	N-terminal pro-hormone B-type natriuretic peptide
Renal	BUN
	Creatinine
	eGFR
Liver	Albumin
	Transaminases (AST, ALT)
	Alkaline phosphatase
	Gamma-glutamyl transferase (GGT)
	Bilirubin
	INR
	MELD score (requires creatinine, bilirubin, INR, sodium)
Hematologic	WBC (with differential)
	Hemoglobin and hematocrit
	Platelets

ALT = alanine aminotransferase; AST = aspartate aminotransferase; BUN = blood urea nitrogen; eGFR = estimated glomerular filtration rate; INR = international normalized ratio; MELD = model for end-stage liver disease; WBC = white blood cell.